학술논문
Increased TMEM166 Level in Patients with Postoperative Stroke after Carotid Endarterectomy.
Document Type
Academic Journal
Author
Chen Y; Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Wang D; Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Yin J; Department of Anesthesiology, the First Affiliated Hospital of Xinxiang Medical University, Henan, China.; Krafft PR; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Luo X; Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Hao D; Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Li C; Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Liu Y; Department of Anaesthesiology, Beijing Obstetrics and Gynecology Hospital,Capital Medical University, Beijing, China. Electronic address: liuye@mail.ccmu.edu.cn.; Li L; Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: li_anethesia@163.com.; Zhang Y; Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: yongbozhang@ccmu.edu.cn.; Zhu C; Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: dr_zhuchen@hotmail.com.
Source
Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
Subject
Language
English
Abstract
Postoperative stroke is a challenging and potentially devastating complication after elective carotid endarterectomy (CEA). We previously demonstrated that transmembrane protein 166 (TMEM166) levels were directly related to neuronal damage after cerebral ischemia-reperfusion injury in rats. In this subsequent clinical study, we aimed to evaluate the prognostic value of TMEM166 in patients suffering from post-CEA strokes. Thirty-five patients undergoing uncomplicated elective CEA and 8 patients who suffered ischemic strokes after CEA were recruited. We evaluated the protein level and expression of TMEM166 in patients diagnosed with postoperative strokes and compared it to those in patients who underwent uncomplicated elective CEA. Blood samples and carotid artery plaques were collected and analyzed. High expressions of TMEM166 were detected by immunofluorescence staining and Western Blot in carotid artery plaques of all patients who underwent CEA. Furthermore, circulating TMEM166 concentrations were statistically higher in post-CEA stroke patients than in patients allocated to the control group. Mean plasma concentrations of inflammatory markers, including interleukin 6 (IL-6) and C-reactive protein (CRP), were also elevated in patients with postoperative strokes. Therefore, based on these findings, we hypothesize that elevated TMEM166 levels, accompanied by a strong inflammatory response, serve as a useful biomarker for risk assessment of postoperative stroke following CEA.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)