학술논문
Electric shock causes a fleeing-like persistent behavioral response in the nematode Caenorhabditis elegans.
Document Type
Academic Journal
Author
Tee LF; Graduate School of Science, Nagoya City University, Nagoya 467-8501, Japan.; Young JJ; Mills College at Northeastern University, Oakland, CA 94613, USA.; Maruyama K; Graduate School of Science, Nagoya City University, Nagoya 467-8501, Japan.; Kimura S; Graduate School of Science, Nagoya City University, Nagoya 467-8501, Japan.; Suzuki R; Graduate School of Science, Nagoya City University, Nagoya 467-8501, Japan.; Endo Y; Graduate School of Science, Nagoya City University, Nagoya 467-8501, Japan.; Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.; Kimura KD; Graduate School of Science, Nagoya City University, Nagoya 467-8501, Japan.; Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
Source
Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE
Subject
Language
English
Abstract
Behavioral persistency reflects internal brain states, which are the foundations of multiple brain functions. However, experimental paradigms enabling genetic analyses of behavioral persistency and its associated brain functions have been limited. Here, we report novel persistent behavioral responses caused by electric stimuli in the nematode Caenorhabditis elegans. When the animals on bacterial food are stimulated by alternating current, their movement speed suddenly increases 2- to 3-fold, persisting for more than 1 minute even after a 5-second stimulation. Genetic analyses reveal that voltage-gated channels in the neurons are required for the response, possibly as the sensors, and neuropeptide signaling regulates the duration of the persistent response. Additional behavioral analyses implicate that the animal's response to electric shock is scalable and has a negative valence. These properties, along with persistence, have been recently regarded as essential features of emotion, suggesting that C. elegans response to electric shock may reflect a form of emotion, akin to fear.
Competing Interests: Conflicts of interest The author(s) declare no conflict of interest.
(© The Author(s) 2023. Published by Oxford University Press on behalf of The Genetics Society of America.)
Competing Interests: Conflicts of interest The author(s) declare no conflict of interest.
(© The Author(s) 2023. Published by Oxford University Press on behalf of The Genetics Society of America.)