학술논문
Long-term pulmonary outcomes of young adults born prematurely: a Polish prospective cohort study PREMATURITAS 20.
Document Type
Academic Journal
Author
Walicka-Serzysko K; Cystic Fibrosis Department, Institute of Mother and Child, Warsaw, Poland. katarzyna.walicka@imid.med.pl.; Cystic Fibrosis Centre, Pediatric Hospital, Dziekanów Leśny, Poland. katarzyna.walicka@imid.med.pl.; Postek M; Cystic Fibrosis Department, Institute of Mother and Child, Warsaw, Poland.; Cystic Fibrosis Centre, Pediatric Hospital, Dziekanów Leśny, Poland.; Borawska-Kowalczyk U; Cystic Fibrosis Department, Institute of Mother and Child, Warsaw, Poland.; Cystic Fibrosis Centre, Pediatric Hospital, Dziekanów Leśny, Poland.; Szamotulska K; Department of Epidemiology and Biostatistics, Institute of Mother and Child, Warsaw, Poland.; Kwaśniewicz P; Diagnostic Imaging Department, Institute of Mother and Child, Warsaw, Poland.; Polak K; Neonatology Clinic, Institute of Mother and Child, Warsaw, Poland.; Mierzejewska E; Department of Epidemiology and Biostatistics, Institute of Mother and Child, Warsaw, Poland.; Sands D; Cystic Fibrosis Department, Institute of Mother and Child, Warsaw, Poland.; Cystic Fibrosis Centre, Pediatric Hospital, Dziekanów Leśny, Poland.; Rutkowska M; Department of Epidemiology and Biostatistics, Institute of Mother and Child, Warsaw, Poland.
Source
Publisher: BioMed Central Country of Publication: England NLM ID: 100968563 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2466 (Electronic) Linking ISSN: 14712466 NLM ISO Abbreviation: BMC Pulm Med Subsets: MEDLINE
Subject
Language
English
Abstract
Background: The long-term consequences of prematurity are often not sufficiently recognized. To address this gap, a prospective cohort study, which is a continuation of the multicenter Polish study PREMATURITAS, was conducted, utilizing unique clinical data from 20 years ago.
Objective: The main goal was to evaluate lung function, detect any structural abnormalities using lung ultrasound, and assess psychological well-being in young adults born between 24 and 34 weeks of gestational age (GA). Additionally, the study aimed to investigate potential associations between perinatal risk factors and abnormalities observed in pulmonary function tests (PFTs) during adulthood.
Methods: The young survivors underwent a comprehensive set of PFTs, a lung ultrasound, along with the quality of life assessment. Information regarding the neonatal period and respiratory complications was obtained from the baseline data collected in the PREMATURITAS study.
Results: A total of 52 young adults, with a mean age of 21.6 years, underwent PFTs. They were divided into two groups based on GA: 24-28 weeks (n = 12) and 29-34 weeks (n = 40). The subgroup born more prematurely had significantly higher lung clearance index (LCI), compared to the other subgroup (p = 0.013). LCI ≥ 6.99 was more frequently observed in the more premature group (50% vs. 12.5%, p = 0.005), those who did not receive prenatal steroids (p = 0.020), with a diagnosis of Respiratory Distress Syndrome (p = 0.034), those who received surfactant (p = 0.026), and mechanically ventilated ≥ 7 days (p = 0.005). Additionally, elevated LCI was associated with the diagnosis of asthma (p = 0.010).
Conclusions: The findings suggest pulmonary effects due to prematurity persist into adulthood and their insult on small airway function. Regular follow-up evaluations of young survivors born preterm should include assessments of PFTs. Specifically, the use of LCI can provide valuable insights into long-term pulmonary impairment.
(© 2024. The Author(s).)
Objective: The main goal was to evaluate lung function, detect any structural abnormalities using lung ultrasound, and assess psychological well-being in young adults born between 24 and 34 weeks of gestational age (GA). Additionally, the study aimed to investigate potential associations between perinatal risk factors and abnormalities observed in pulmonary function tests (PFTs) during adulthood.
Methods: The young survivors underwent a comprehensive set of PFTs, a lung ultrasound, along with the quality of life assessment. Information regarding the neonatal period and respiratory complications was obtained from the baseline data collected in the PREMATURITAS study.
Results: A total of 52 young adults, with a mean age of 21.6 years, underwent PFTs. They were divided into two groups based on GA: 24-28 weeks (n = 12) and 29-34 weeks (n = 40). The subgroup born more prematurely had significantly higher lung clearance index (LCI), compared to the other subgroup (p = 0.013). LCI ≥ 6.99 was more frequently observed in the more premature group (50% vs. 12.5%, p = 0.005), those who did not receive prenatal steroids (p = 0.020), with a diagnosis of Respiratory Distress Syndrome (p = 0.034), those who received surfactant (p = 0.026), and mechanically ventilated ≥ 7 days (p = 0.005). Additionally, elevated LCI was associated with the diagnosis of asthma (p = 0.010).
Conclusions: The findings suggest pulmonary effects due to prematurity persist into adulthood and their insult on small airway function. Regular follow-up evaluations of young survivors born preterm should include assessments of PFTs. Specifically, the use of LCI can provide valuable insights into long-term pulmonary impairment.
(© 2024. The Author(s).)