학술논문
Layer-specific strain in patients with cardiac amyloidosis using tissue tracking MR.
Document Type
Academic Journal
Author
Li Z; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Shanghai Institute of Cardiovascular Disease, Shanghai, China.; Shanghai Institute of Medical Imaging, Shanghai, China.; Yan C; Shanghai Institute of Medical Imaging, Shanghai, China.; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.; Hu GX; Shanghai Institute of Medical Imaging, Shanghai, China.; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.; Zhao R; Department of Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, United States.; Jin H; Shanghai Institute of Medical Imaging, Shanghai, China.; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.; Yun H; Shanghai Institute of Medical Imaging, Shanghai, China.; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.; Wei Z; Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China.; Pan CZ; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Shanghai Institute of Cardiovascular Disease, Shanghai, China.; Shanghai Institute of Medical Imaging, Shanghai, China.; Shu XH; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Shanghai Institute of Cardiovascular Disease, Shanghai, China.; Shanghai Institute of Medical Imaging, Shanghai, China.; Zeng MS; Shanghai Institute of Medical Imaging, Shanghai, China.; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Source
Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 9918367586306676 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-8740 (Electronic) Linking ISSN: 26738740 NLM ISO Abbreviation: Front Radiol Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Background: Cardiac infiltration is the major predictor of poor prognosis in patients with systemic amyloidosis, thus it becomes of great importance to evaluate cardiac involvement.
Purpose: We aimed to evaluate left ventricular myocardial deformation alteration in patients with cardiac amyloidosis (CA) using layer-specific tissue tracking MR.
Material and Methods: Thirty-nine patients with CA were enrolled. Thirty-nine normal controls were also recruited. Layer-specific tissue tracking analysis was done based on cine MR images.
Results: Compared with the control group, a significant reduction in LV whole layer strain values (GLS, GCS, and GRS) and layer-specific strain values was found in patients with CA (all P < 0.01). In addition, GRS and GLS, as well as subendocardial and subepicardial GLS, GRS, and GCS, were all diminished in patients with CA and reduced LVEF, when compared to those with preserved or mid-range LVEF (all P < 0.05). GCS showed the largest AUC (0.9952, P = 0.0001) with a sensitivity of 93.1% and specificity of 90% to predict reduced LVEF (<40%). Moreover, GCS was the only independent predictor of LV systolic dysfunction (Odds Ratio: 3.30, 95% CI:1.341-8.12, and P = 0.009).
Conclusion: Layer-specific tissue tracking MR could be a useful method to assess left ventricular myocardial deformation in patients with CA.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author ZL declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
(© 2023 Li, Yan, Hu, Zhao, Jin, Yun, Wei, Pan, Shu and Zeng.)
Purpose: We aimed to evaluate left ventricular myocardial deformation alteration in patients with cardiac amyloidosis (CA) using layer-specific tissue tracking MR.
Material and Methods: Thirty-nine patients with CA were enrolled. Thirty-nine normal controls were also recruited. Layer-specific tissue tracking analysis was done based on cine MR images.
Results: Compared with the control group, a significant reduction in LV whole layer strain values (GLS, GCS, and GRS) and layer-specific strain values was found in patients with CA (all P < 0.01). In addition, GRS and GLS, as well as subendocardial and subepicardial GLS, GRS, and GCS, were all diminished in patients with CA and reduced LVEF, when compared to those with preserved or mid-range LVEF (all P < 0.05). GCS showed the largest AUC (0.9952, P = 0.0001) with a sensitivity of 93.1% and specificity of 90% to predict reduced LVEF (<40%). Moreover, GCS was the only independent predictor of LV systolic dysfunction (Odds Ratio: 3.30, 95% CI:1.341-8.12, and P = 0.009).
Conclusion: Layer-specific tissue tracking MR could be a useful method to assess left ventricular myocardial deformation in patients with CA.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author ZL declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
(© 2023 Li, Yan, Hu, Zhao, Jin, Yun, Wei, Pan, Shu and Zeng.)