학술논문
Is the Severity of the Clinical Expression of Anorexia Nervosa Influenced by an Anxiety, Depressive, or Obsessive-Compulsive Comorbidity Over a Lifetime?
Document Type
Academic Journal
Author
Riquin E; Department of Child and Adolescent Psychiatry, Centre Hospitalier Universitaire d'Angers [Angers University Hospital], Angers, France.; Laboratory of Psychology, LPPL EA4638, University of Angers, Angers, France.; Adolescent and Young Adult University Hospital Department of the Health Foundation of Students of France, Centre Pierre Daguet, Sablé-sur-Sarthe, France.; Raynal A; Department of Child and Adolescent Psychiatry, CH du Rouvray-CHU de Rouen, Rouen, France.; Mattar L; Nutrition Division, Department of Natural Sciences, School of Arts and Sciences-Lebanese American University, Beirut, Lebanon.; Lalanne C; Université Paris Diderot [Paris Diderot University], Paris Sorbonne Cité, Paris, France.; Hirot F; CESP, Univ. Paris-Sud, UVSQ, INSERM U 1178, Université Paris-Saclay [Paris-Saclay University], Paris, France.; Department of Psychiatry for Adolescents and Young Adults, Institut Mutualiste Montsouris, Paris, France.; Huas C; CESP, Univ. Paris-Sud, UVSQ, INSERM U 1178, Université Paris-Saclay [Paris-Saclay University], Paris, France.; Adolescent and Young Adult University Hospital Department of the Health Foundation of Students of France, Paris, France.; Duclos J; Univ. Lille, CNRS, CHU Lille, UMR 9193-SCALab-Cognitive and Affective Sciences, Lille, France.; Hôpital Saint Vincent de Paul, GHICL, Département de Psychiatrie, Paris, France.; Berthoz S; Department of Psychiatry for Adolescents and Young Adults, Institut Mutualiste Montsouris, Paris, France.; Univ. Bordeaux INCIA CNRS UMR 5287, Bordeaux, France.; Godart N; CESP, Univ. Paris-Sud, UVSQ, INSERM U 1178, Université Paris-Saclay [Paris-Saclay University], Paris, France.; Department of Psychiatry for Adolescents and Young Adults, Institut Mutualiste Montsouris, Paris, France.; Adolescent and Young Adult University Hospital Department of the Health Foundation of Students of France, Paris, France.; UFR des Sciences de la Santé Simone Veil [Simone Veil Health Science Training and Research Unit], Université de Versailles Saint-Quentin-en-Yvelines [Versailles Saint-Quentin-en-Yvelines University], Versailles, France.
Source
Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101545006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-0640 (Print) Linking ISSN: 16640640 NLM ISO Abbreviation: Front Psychiatry Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1664-0640
Abstract
Purpose: The relationship between anxiety or depressive comorbidities, their chronology of onset, and the severity of anorexia nervosa (AN) is not well-studied. We hypothesize that the existence of a comorbidity, particularly before the onset of AN, is associated with greater severity of AN. Methods: One hundred seventy-seven subjects were assessed. The prevalence of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), and social phobia (SP) as well as their chronology of onset were studied. The assessment criteria of AN severity were the overall clinical condition, body mass index (BMI) on admission, lowest BMI, intensity of the eating symptoms, age at the onset of AN, illness duration, number of hospitalizations, and quality of life. Results: Patients with AN had the greatest clinical severity when they had a comorbid disorder over their lifetime, such as MDD, GAD, or SP. These comorbidities along with OCD were associated with a higher level of eating symptoms and a more altered quality of life. A profile of maximum severity was associated with a higher prevalence of MDD and GAD. Concerning the chronology of onset, the age at the start of AN was later in cases of MDD or GAD prior to AN. Conclusion: There seems to be an association between severity of AN and both MDD and GAD. The chronology of onset of the comorbidity did not seem to be associated with the severity.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Riquin, Raynal, Mattar, Lalanne, Hirot, Huas, Duclos, Berthoz, Godart and EVHAN group.)
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Riquin, Raynal, Mattar, Lalanne, Hirot, Huas, Duclos, Berthoz, Godart and EVHAN group.)