학술논문
Association of singlenucleotide NR3C1 gene polymorphisms with glucocorticosteroid responsiveness in patients with pemphigus vulgaris.
Document Type
Academic Journal
Author
Le TVT; Department of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City; Department of Dermatology and Skin Aesthetics, University Medical Center HCMC.; Nguyen DQ; Department of Dermatology.; Tran ND; Faculty of Public Health.; Tu Trinh HK; Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam.
Source
Publisher: PAGEPress Country of Publication: Italy NLM ID: 101566470 Publication Model: eCollection Cited Medium: Print ISSN: 2036-7392 (Print) Linking ISSN: 20367392 NLM ISO Abbreviation: Dermatol Reports Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2036-7392
Abstract
The glucocorticosteroid (GC) is crucial when managing patients with pemphigus vulgaris (PV). Polymorphisms in the gene encoding the nuclear receptor subfamily 3, group C, member 1 ( NR3C1 ) protein (the GC receptor) may explain the variations in treatment efficacy. We evaluated the effects of 10 single nucleotide polymorphisms (SNPs) in the NR3C1 gene and the correlations with the GC responsiveness in patients with PV. The accumulative GC doses were recorded, and patients were assessed for the Pemphigus Disease Activity Index (PDAI) scores until the GC doses would be tapered. Whole blood samples at the initial visit were genotyped using TaqMan SNP Genotyping. In the NR3C1 gene, SNPs were detected in 6 (rs17209237, rs11745958, rs7701443, rs41423247, rs33388, and rs6196); the genotypes rs17209237 AA , rs11745958 CC , and rs6196 AG may be associated with a need for a lower accumulative GC dose; rs17209237 AA and rs6196 AG with shorter times to commencement of tapering; and rs17209237 AA and rs11745958 CC with shorter times to attainment of 50 and 25% PDAI scores. Thus, NR3C1 gene variations may predict GC responsiveness in PV patients.
Competing Interests: Conflict of interest: The authors declare no potential conflict of interest.
(©Copyright: the Author(s).)
Competing Interests: Conflict of interest: The authors declare no potential conflict of interest.
(©Copyright: the Author(s).)