학술논문

The Los Angeles motor scale (LAMS) is independently associated with CT perfusion collateral status markers.
Document Type
Academic Journal
Author
Lakhani DA; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA. Electronic address: dhairyalakhani@gmail.com.; Mehta TR; Department of Neurology, University of missouri, Columbia, MO, USA.; Balar AB; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Koneru M; Cooper Medical School of Rowan University, Camden, NJ, USA.; Wen S; Department of Biostatistics, West Virginia University, Morgantown, WV, USA.; Ozkara BB; Department of Neuroradiology, MD Anderson Medical Center, Houston, TX.; Caplan J; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.; Dmytriw AA; Department of Radiology, Harvard Medical School, Boston, MA, USA.; Wang R; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Lu H; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Hoseinyazdi M; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Nabi M; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Mazumdar I; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Cho A; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Chen K; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Sepehri S; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Hyson N; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Xu R; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Urrutia V; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Luna L; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.; Hillis AH; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.; Heit JJ; Department of Neurology, Stanford University, Stanford, CA, USA.; Albers GW; Department of Neurology, Stanford University, Stanford, CA, USA.; Rai AT; Department of Neuroradiology, West Virginia University, Morgantown, WV, USA.; Faizy TD; Department of Radiology, Neuroendovascular Division - University Medical Center Münster, Germany.; Wintermark M; Department of Neuroradiology, MD Anderson Medical Center, Houston, TX.; Nael K; Division of Neuroradiology, Department of Radiology, University of California San Francisco, CA, USA.; Yedavalli VS; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
Source
Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 9433352 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2653 (Electronic) Linking ISSN: 09675868 NLM ISO Abbreviation: J Clin Neurosci Subsets: MEDLINE
Subject
Language
English
Abstract
Background and Aim: The Los Angeles Motor Scale (LAMS) is an objective tool that has been used to rapidly assess and predict the presence of large vessel occlusion (LVO) in the pre-hospital setting successfully in several studies. However, studies assessing the relationship between LAMS score and CT perfusion collateral status (CS) markers such as cerebral blood volume (CBV) index, and hypoperfusion intensity ratio (HIR) are sparse. Our study therefore aims to assess the association of admission LAMS score with established CTP CS markers CBV Index and HIR in AIS-LVO cases.
Materials and Methods: In this prospectively collected, retrospectively reviewed analysis, inclusion criteria were as follows: a) CT angiography (CTA) confirmed anterior circulation LVO from 9/1/2017 to 10/01/2023, and b) diagnostic CT perfusion (CTP). Logistic regression analysis was performed to assess the relationship between admission LAMS with CTP CS markers HIR and CBV Index. p ≤ 0.05 was considered significant.
Results: In total, 285 consecutive patients (median age = 69 years; 56 % female) met our inclusion criteria. Multivariable logistic regression analysis adjusting for sex, age, ASPECTS, tPA, premorbid mRS, admission NIH stroke scale, prior history of TIA, stroke, atrial fibrillation, diabetes mellitus, hyperlipidemia, coronary artery disease and hypertension, admission LAMS was found to be independently associated with CBV Index (adjusted OR:0.82, p < 0.01), and HIR (adjusted OR:0.59, p < 0.05).
Conclusion: LAMS is independently associated with CTP CS markers, CBV index and HIR. This finding suggests that LAMS may also provide an indirect estimate of CS.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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