학술논문
Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome.
Document Type
Academic Journal
Author
Klobučar I; Department of Cardiology, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia.; Habisch H; Otto Loewi Research Center, Medicinal Chemistry, Medical University of Graz, 8010 Graz, Austria.; Klobučar L; Department of Medicine, University Hospital Centre Osijek, 31000 Osijek, Croatia.; Trbušić M; Department of Cardiology, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.; Pregartner G; Institute for Medical Informatics, Statistics, and Documentation, Medical University of Graz, 8036 Graz, Austria.; Berghold A; Institute for Medical Informatics, Statistics, and Documentation, Medical University of Graz, 8036 Graz, Austria.; Kostner GM; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.; Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.; Madl T; Otto Loewi Research Center, Medicinal Chemistry, Medical University of Graz, 8010 Graz, Austria.; BioTechMed-Graz, 8010 Graz, Austria.; Frank S; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.; BioTechMed-Graz, 8010 Graz, Austria.; Degoricija V; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.; Department of Medicine, Sisters of Charity University Hospital Centre, 10000 Zagreb, Croatia.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Subject
Language
English
Abstract
Metabolic syndrome (MS) is a widespread disease in developed countries, accompanied, among others, by decreased adiponectin serum levels and perturbed lipoprotein metabolism. The associations between the serum levels of adiponectin and lipoproteins have been extensively studied in the past under healthy conditions, yet it remains unexplored whether the observed associations also exist in patients with MS. Therefore, in the present study, we analyzed the serum levels of lipoprotein subclasses using nuclear magnetic resonance spectroscopy and examined their associations with the serum levels of adiponectin in patients with MS in comparison with healthy volunteers (HVs). In the HVs, the serum levels of adiponectin were significantly negatively correlated with the serum levels of large buoyant-, very-low-density lipoprotein, and intermediate-density lipoprotein, as well as small dense low-density lipoprotein (LDL) and significantly positively correlated with large buoyant high-density lipoprotein (HDL). In patients with MS, however, adiponectin was only significantly correlated with the serum levels of phospholipids in total HDL and large buoyant LDL. As revealed through logistic regression and orthogonal partial least-squares discriminant analyses, high adiponectin serum levels were associated with low levels of small dense LDL and high levels of large buoyant HDL in the HVs as well as high levels of large buoyant LDL and total HDL in patients with MS. We conclude that the presence of MS weakens or abolishes the strong associations between adiponectin and the lipoprotein parameters observed in HVs and disturbs the complex interplay between adiponectin and lipoprotein metabolism.