학술논문
Changes in Lipoprotein(a) Levels in People after ST Elevation Myocardial Infarction-The STEMI-Lipids Study.
Document Type
Academic Journal
Author
Sourij C; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; Aziz F; Trials Unit for Interdisciplinary Metabolic Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; Krappinger S; Trials Unit for Interdisciplinary Metabolic Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; Praschk A; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; Metzner T; Department of Medical Affairs, Eli Lilly GmbH, Erdberger Lände 26A, 1030 Vienna, Austria.; Kojzar H; Trials Unit for Interdisciplinary Metabolic Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; Zirlik A; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; Stojakovic T; Clinical Institute of Medical- and Chemical Laboratory Diagnostics, University Hospital Graz, 8036 Graz, Austria.; Pätzold D; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; von Lewinski D; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; Zweiker R; Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.; Scharnagl H; Clinical Institute of Medical- and Chemical Laboratory Diagnostics, University Hospital Graz, 8036 Graz, Austria.; Sourij H; Trials Unit for Interdisciplinary Metabolic Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Subject
Language
English
Abstract
Lipoprotein(a) (Lp(a)) is considered an independent risk factor for cardiovascular diseases. The plasma concentration of Lp(a) is largely genetically determined but varies over a wide range within the population. This study investigated changes in Lp(a) levels after an acute myocardial infarction. Patients who underwent coronary angiography due to an ST elevation myocardial infarction were enrolled ( n = 86), and Lp(a) levels were measured immediately after the intervention, one day, two days, and at a post-discharge follow-up visit at 3 to 6 months after the acute myocardial infarction. Median Lp(a) levels increased from a median of 7.9 mg/dL (3.8-37.1) at hospital admission to 8.4 mg/dL (3.9-35.4) on the following day, then to 9.3 mg/dL (3.7-39.1) on day two ( p < 0.001), and to 11.2 mg/dL (4.4-59.6) at the post-discharge follow-up ( p < 0.001). Lp(a) levels were the lowest during the acute myocardial infarction and started to increase significantly immediately thereafter, with the highest levels at the post-discharge follow-up. The moderate but significant increase in Lp(a) in people with acute myocardial infarction appears to be clinically relevant on an individual basis, especially when specific Lp(a) cut-off levels are supposed to determine the initiation of future treatment. Hence, a repeated measurement of Lp(a) after myocardial infarction should be performed.