학술논문
Atrial fibrillation cycle-length (AF-CL) inside the pulmonary veins predicts paroxysmal AF ablation success- the INDUCE-AF study.
Document Type
Academic Journal
Author
Bergonti M; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium. bergmar21@gmail.com.; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, 6900, Lugano, Switzerland. bergmar21@gmail.com.; Ascione C; CHU Bordeaux, University of Bordeaux, Bordeaux, France.; L'Institut de RYthmologie Et Modélisation Cardiaque (LIRYC), ANR-10-IAHU-04, Université de Bordeaux, Bordeaux, France.; Compagnucci P; Cardiology and Arrhythmology Clinic, University Hospital 'Ospedali Riuniti Umberto I-Lancisi-Salesi', Ancona, Italy.; Marcon L; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Van Leuven O; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Saenen J; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Huybrechts W; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Miljoen H; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Casella M; Cardiology and Arrhythmology Clinic, University Hospital 'Ospedali Riuniti Umberto I-Lancisi-Salesi', Ancona, Italy.; Valeri Y; Cardiology and Arrhythmology Clinic, University Hospital 'Ospedali Riuniti Umberto I-Lancisi-Salesi', Ancona, Italy.; Jaïs P; CHU Bordeaux, University of Bordeaux, Bordeaux, France.; L'Institut de RYthmologie Et Modélisation Cardiaque (LIRYC), ANR-10-IAHU-04, Université de Bordeaux, Bordeaux, France.; Sacher F; CHU Bordeaux, University of Bordeaux, Bordeaux, France.; L'Institut de RYthmologie Et Modélisation Cardiaque (LIRYC), ANR-10-IAHU-04, Université de Bordeaux, Bordeaux, France.; Heidbuchel H; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Antwerp, Belgium.; Sarkozy A; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.; Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Laarbeeklaan 101, 1090, Brussels, Belgium.
Source
Publisher: Springer Country of Publication: Netherlands NLM ID: 9708966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-8595 (Electronic) Linking ISSN: 1383875X NLM ISO Abbreviation: J Interv Card Electrophysiol Subsets: MEDLINE
Subject
Language
English
Abstract
Background: A novel method to measure atrial fibrillation cycle length (AF-CL) was recently described, based on the average of 10 consecutive signals (FARS10). FARS10 accurately identified pulmonary vein isolation (PVI)-responders among patients with persistent AF. Whether this method is applicable to patients with paroxysmal AF is unknown.
Objective: The aim of this study is to evaluate the prognostic value of FARS10 measurements in patients with paroxysmal AF.
Methods and Results: We enrolled paroxysmal AF patients undergoing PVI in a prospective multicenter study. After AF induction with a standardized protocol, the AF-CL was measured using FARS-10 method. The primary endpoint was AF/AT-recurrence. One-hundred and four patients were included (61 ± 14 years, 25% females). After a mean follow-up of 12 ± 4 months, AF/AT recurrence rate was 20%. The fastest PV CL (fPV-CL) was independently associated with the primary endpoint at multivariate analysis (HR 1.02, p < 0.001). Every 10 ms increase in fPV-CL, AF recurrences increased by 20%. The value of 160 ms was found to be the optimal cut-off (specificity 81%, sensitivity 76%). Patients with fPV-CL < 160 ms experienced lower AF recurrences as compared to patients with fPV-CL > 160 ms (8% vs. 32% at 1 year; HR = 0.17, p < 0.001). Progression to persistent AF was observed in 13% of patients with fPV-CL > 160 ms.
Conclusion: fPV-CL measured with the FARS-10 method accurately predicts PVI success in paroxysmal AF patients undergoing PVI. Patients with slow PV activity (fPV-CL > 160 ms) experience higher AF recurrence rate after PVI and more frequent progression to persistent AF.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Objective: The aim of this study is to evaluate the prognostic value of FARS10 measurements in patients with paroxysmal AF.
Methods and Results: We enrolled paroxysmal AF patients undergoing PVI in a prospective multicenter study. After AF induction with a standardized protocol, the AF-CL was measured using FARS-10 method. The primary endpoint was AF/AT-recurrence. One-hundred and four patients were included (61 ± 14 years, 25% females). After a mean follow-up of 12 ± 4 months, AF/AT recurrence rate was 20%. The fastest PV CL (fPV-CL) was independently associated with the primary endpoint at multivariate analysis (HR 1.02, p < 0.001). Every 10 ms increase in fPV-CL, AF recurrences increased by 20%. The value of 160 ms was found to be the optimal cut-off (specificity 81%, sensitivity 76%). Patients with fPV-CL < 160 ms experienced lower AF recurrences as compared to patients with fPV-CL > 160 ms (8% vs. 32% at 1 year; HR = 0.17, p < 0.001). Progression to persistent AF was observed in 13% of patients with fPV-CL > 160 ms.
Conclusion: fPV-CL measured with the FARS-10 method accurately predicts PVI success in paroxysmal AF patients undergoing PVI. Patients with slow PV activity (fPV-CL > 160 ms) experience higher AF recurrence rate after PVI and more frequent progression to persistent AF.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)