학술논문
Structural and metabolic correlates of neuropsychological profiles in multiple system atrophy and Parkinson's disease.
Document Type
Academic Journal
Author
Kübler D; Movement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany. Electronic address: dorothee.kuebler@charite.de.; Kobylecki C; Department of Neurology, Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; Wolfson Molecular Imaging Centre, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom.; McDonald KR; Wolfson Molecular Imaging Centre, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom.; Anton-Rodriguez JM; Wolfson Molecular Imaging Centre, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom; Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom.; Herholz K; Wolfson Molecular Imaging Centre, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom.; Carter SF; Wolfson Molecular Imaging Centre, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.; Hinz R; Wolfson Molecular Imaging Centre, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom.; Thompson JC; Department of Neurology, Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.; Al-Fatly B; Movement Disorder and Neuromodulation Unit, Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.; Gerhard A; Wolfson Molecular Imaging Centre, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom; Departments of Geriatric Medicine and Nuclear Medicine, Center for Translational Neuro- and Behavioral Sciences, University Medicine Essen, Essen, Germany.
Source
Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Despite increased recognition of cognitive impairment in Multiple System Atrophy (MSA), its neuroanatomical correlates are not well defined. We aimed to explore cognitive profiles in MSA with predominant parkinsonism (MSA-P) and Parkinson's disease (PD) and their relationship to frontostriatal structural and metabolic changes.
Methods: Detailed clinical and neuropsychological evaluation was performed together with diffusion tensor imaging (DTI) and [18 F]-fluoro-deoxyglucose positron emission tomography ([ 18 F]-FDG-PET) in patients with MSA-P (n = 11) and PD (n = 11). We compared clinical and neuropsychological data to healthy controls (n = 9) and correlated neuropsychological data with imaging findings in MSA-P and PD.
Results: Patients with MSA-P showed deficits in executive function (Trail Making Test B-A) and scored higher in measures of depression and anxiety compared to those with PD and healthy controls. Widespread frontostriatal white matter tract reduction in fractional anisotropy was seen in MSA-P and PD compared to an imaging control group. Stroop Test interference performance correlated with [18 F]-FDG uptake in the bilateral dorsolateral prefrontal cortex (DLPFC) and with white matter integrity between the striatum and left inferior frontal gyrus (IFG) in PD. Trail Making Test performance correlated with corticostriatal white matter integrity along tracts from the bilateral IFG in MSA-P and from the right DLPFC in both groups.
Conclusion: Executive dysfunction was more prominent in patients with MSA-P compared to PD. DLPFC metabolism and frontostriatal white matter integrity seem to be a driver of executive function in PD, whereas alterations in corticostriatal white matter integrity may contribute more to executive dysfunction in MSA-P.
Competing Interests: Declaration of competing interest No conflicts of interest are reported.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Methods: Detailed clinical and neuropsychological evaluation was performed together with diffusion tensor imaging (DTI) and [
Results: Patients with MSA-P showed deficits in executive function (Trail Making Test B-A) and scored higher in measures of depression and anxiety compared to those with PD and healthy controls. Widespread frontostriatal white matter tract reduction in fractional anisotropy was seen in MSA-P and PD compared to an imaging control group. Stroop Test interference performance correlated with [
Conclusion: Executive dysfunction was more prominent in patients with MSA-P compared to PD. DLPFC metabolism and frontostriatal white matter integrity seem to be a driver of executive function in PD, whereas alterations in corticostriatal white matter integrity may contribute more to executive dysfunction in MSA-P.
Competing Interests: Declaration of competing interest No conflicts of interest are reported.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)