학술논문
Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastases.
Document Type
Academic Journal
Author
Leduc S; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; Nguyen HL; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; Richard F; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; Zels G; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; Mahdami A; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; De Schepper M; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.; Maetens M; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; Pabba A; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; Jaekers J; Department of Visceral Surgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.; Latacz E; Translational Cancer Research Unit, GZA Hospitals Antwerp, Antwerp, Belgium.; Bohlok A; Department of Surgical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.; Vanderheyden E; Laboratory of Translational Genetics, VIB-KU Leuven, Leuven, Belgium.; Van Brussel T; Laboratory of Translational Genetics, VIB-KU Leuven, Leuven, Belgium.; Boeckx B; Laboratory of Translational Genetics, VIB-KU Leuven, Leuven, Belgium.; Schepers R; Laboratory of Translational Genetics, VIB-KU Leuven, Leuven, Belgium.; Lambrechts D; Laboratory of Translational Genetics, VIB-KU Leuven, Leuven, Belgium.; Dirix L; Translational Cancer Research Unit, GZA Hospitals Antwerp, Antwerp, Belgium.; Larsimont D; Department of Anatomopathology, Institut Jules Bordet, Brussels, Belgium.; Vankerckhove S; Department of Surgical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.; Lucidi V; Department of Abdominal Surgery, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.; Topal B; Department of Visceral Surgery, University Hospitals Leuven, KU Leuven, Leuven, Belgium.; Bachir I; Department of Anesthesiology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.; Donckier V; Department of Surgical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.; Floris G; Department of Pathology, University Hospitals Leuven, Leuven, Belgium.; Department of Imaging and Pathology, Laboratory of Translational Cell & Tissue Research and University Hospitals Leuven, KU Leuven, Leuven, Belgium.; Vermeulen P; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium.; Translational Cancer Research Unit, GZA Hospitals Antwerp, Antwerp, Belgium.; Desmedt C; Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Herestraat 49, box 810, Leuven, 3000, Belgium. Christine.desmedt@kuleuven.be.
Source
Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 8409970 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7276 (Electronic) Linking ISSN: 02620898 NLM ISO Abbreviation: Clin Exp Metastasis Subsets: MEDLINE
Subject
Language
English
Abstract
Metastatic breast cancer (mBC) remains incurable and liver metastases (LM) are observed in approximately 50% of all patients with mBC. In some cases, surgical resection of breast cancer liver metastases (BCLM) is associated with prolonged survival. However, there are currently no validated marker to identify these patients. The interactions between the metastatic cancer cells and the liver microenvironment result in two main histopathological growth patterns (HGP): replacement (r-HGP), characterized by a direct contact between the cancer cells and the hepatocytes, and desmoplastic (d-HGP), in which a fibrous rim surrounds the tumor cells. In patients who underwent resection of BCLM, the r-HGP is associated with a worse postoperative prognosis than the d-HGP. Here, we aim at unraveling the biological differences between these HGP within ten patients presenting both HGP within the same metastasis. The transcriptomic analyses reveal overexpression of genes involved in cell cycle, DNA repair, vessel co-option and cell motility in r-HGP while angiogenesis, wound healing, and several immune processes were found overexpressed in d-HGP LM. Understanding the biology of the LM could open avenues to refine treatment of BC patients with LM.
(© 2024. The Author(s).)
(© 2024. The Author(s).)