학술논문
Racial Differences in Age-Related Changes in Left Ventricular Structural and Functional Echocardiographic Measurements Among Healthy Japanese and American Participants - A Subanalysis of the World Alliance Society of Echocardiography Normal Values Study.
Document Type
Academic Journal
Author
Nakao T; Department of Clinical Laboratory, The University of Tokyo Hospital.; Department of Cardiovascular Medicine, The University of Tokyo Hospital.; Nakanishi K; Department of Cardiovascular Medicine, The University of Tokyo Hospital.; Sawada N; Department of Cardiovascular Medicine, The University of Tokyo Hospital.; Department of Cardiology, NTT Medical Center Tokyo.; Kawahara T; Clinical Research Promotion Center, The University of Tokyo Hospital.; Miyoshi T; Department of Cardiology, Faculty of Medicine, Kindai University.; MedStar Health Research Institute.; Takeuchi M; Department of Laboratory and Transfusion Medicine, Hospital of University of Occupational and Environmental Health, School of Medicine.; Asch FM; MedStar Health Research Institute.; Lang RM; University of Chicago.; Daimon M; Department of Clinical Laboratory, The University of Tokyo Hospital.; Department of Cardiology, International University of Health and Welfare, Mita Hospital.
Source
Publisher: Japanese Circulation Society Country of Publication: Japan NLM ID: 101137683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-4820 (Electronic) Linking ISSN: 13469843 NLM ISO Abbreviation: Circ J Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Age-related changes in left ventricular (LV) structure and function lower the threshold for the onset of heart failure with preserved ejection fraction (HFpEF). LV parameters change also with race; however, the racial differences in age-related changes in LV parameters with and without adjustment for body mass index (BMI), heart rate (HR), and blood pressure (BP) remain unclear.Methods and Results: We performed a subanalysis of the World Alliance Society of Echocardiography Normal Values Study, an international cross-sectional study that examined normal echocardiographic values in 15 countries. The age-related changes in 2-dimensional echocardiographic derived parameters including LV size, systolic function, and mass, were compared between healthy Japanese (n=227) and healthy White (n=98) and Black (n=69) American participants. In men, age-related changes in all parameters did not differ significantly among races. However, compared with Japanese women, White American women had a smaller body surface area (BSA)-indexed LV volume, BSA-indexed LV internal dimension at end-systole, BSA-indexed LV stroke volume, and LV mass index to BSA, and a larger LV ejection fraction with age, even after adjusting for BMI, HR, and BP.
Conclusions: Age-related changes in LV structure and function, which are important for the pathophysiology of HFpEF, may differ by race. Therefore, future studies examining echocardiographic reference values for each age group in each race are needed.
Conclusions: Age-related changes in LV structure and function, which are important for the pathophysiology of HFpEF, may differ by race. Therefore, future studies examining echocardiographic reference values for each age group in each race are needed.