학술논문
Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals.
Document Type
Article
Author
Source
Subject
*CELL nuclei
*HYPOTHALAMUS physiology
*ARTHRITIS in animals
*HYPERALGESIA
*GLUTAMIC acid
*HYPOTHALAMIC-pituitary-adrenal axis
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Language
ISSN
0361-9230
Abstract
Highlights: [•] We investigated the contribution of the dorsomedial nucleus of the hypothalamus (DMH) to arthritis-induced hyperalgesia. [•] Glutamate activation of the DMH increased nociception in controls but not in arthritic animals. [•] The DMH-induced hyperalgesia in controls is tonically mediated by the rostroventromedial medulla. [•] The DMH does not contribute to hyperalgesia induced by arthritis. [ABSTRACT FROM AUTHOR]