학술논문
Sticky Business: Orchestrating Cellular Signals at Adherens Junctions
Document Type
Article
Source
Subject
*EPITHELIUM
*CELLULAR signal transduction
*CELL junctions
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*
Language
ISSN
0092-8674
Abstract
Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions. These junctions and their cytoskeletal associations contribute heavily to the distinct shapes, polarity, spatially oriented mitotic spindle planes, and cellular movements of developing tissues. Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis. [Copyright &y& Elsevier]