학술논문
Hepatitis E, the neglected one.
Document Type
Article
Source
Subject
*HEPATITIS E
*WORLD health
*CIRRHOSIS of the liver
*DEATH rate
*IMMUNOGLOBULIN M
*DIAGNOSIS
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Language
ISSN
1478-3223
Abstract
Hepatitis E virus ( HEV) infection is a worldwide disease. It is the first cause of acute viral hepatitis in the world with an estimated 20 million cases every year and 56 000 deaths. In developing countries, hepatitis E is a waterborne infection. In these countries, HEV genotypes 1 and 2 cause large outbreaks and affect young subjects with a significant mortality rate in pregnant women and patients with cirrhosis. In the developed countries, HEV genotypes 3 and 4 are responsible for autochthonous, sporadic hepatitis and transmission is zoonotic. HEV can cause neurological disorders and in immunocompromised patients, chronic infections. The progression of acute hepatitis E is most often mild and resolves spontaneously. Diagnostic tools include anti- HEV IgM antibodies in serum and/or viral RNA in the blood or stools by PCR. Ribavirin is used to treat chronic infection. A vaccine has been developed in China. [ABSTRACT FROM AUTHOR]