학술논문
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Document Type
Article
Author
Cowell, Annie N.; Istvan, Eva S.; Lukens, Amanda K.; Gomez-Lorenzo, Maria G.; Vanaerschot, Manu; Sakata-Kato, Tomoyo; Flannery, Erika L.; Magistrado, Pamela; Owen, Edward; Abraham, Matthew; LaMonte, Gregory; Painter, Heather J.; Williams, Roy M.; Franco, Virginia; Linares, Maria; Arriaga, Ignacio; Bopp, Selina; Corey, Victoria C.; Gnädig, Nina F.; Coburn-Flynn, Olivia
Source
Subject
*DRUG resistance
*PLASMODIUM
*MALARIA treatment
*GENOMES
*DRUG design
*
*
*
*
Language
ISSN
0036-8075
Abstract
The article presents the results of the study on the antimalarial drug targets and drug-resistance genes of malaria parasites. It states the 159 gene amplifications and 148 nonsynonymous changes in 83 genes associated with drug-resistance acquisition. It cites the hitherto unrecognized drug target-inhibitor pairs. It mentions that the exploration of Plasmodium falciparum resistome and druggable genome will guide drug discovery and structural biology efforts.