학술논문
Imaging evaluation of the cartilage in rheumatoid arthritis patients with an x-ray phase imaging apparatus based on Talbot-Lau interferometry.
Document Type
Article
Author
Yoshioka, Hiroyuki; Kadono, Yuho; Kim, Yoon Taek; Oda, Hiromi; Maruyama, Takashi; Akiyama, Yuji; Mimura, Toshihide; Tanaka, Junji; Niitsu, Mamoru; Hoshino, Yoshihide; Kiyohara, Junko; Nishino, Satoshi; Makifuchi, Chiho; Takahashi, Atsushi; Shinden, Yuko; Matsusaka, Norihiro; Kido, Kazuhiro; Momose, Atsushi
Source
Subject
*CARTILAGE
*RHEUMATOID arthritis
*INTERFEROMETRY
*X-ray imaging
*TUMOR necrosis factors
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Language
ISSN
2045-2322
Abstract
X-ray Talbot-Lau interferometry is one of the x-ray phase imaging methods that has high sensitivity in depicting soft tissues. Unlike earlier x-ray phase imaging methods that required particular types of x-ray sources, such as a synchrotron or a micro-focus x-ray tube, x-ray Talbot-Lau interferometry enables to perform clinical x-ray phase imaging using a conventional x-ray source with a relatively compact configuration. We developed an apparatus to depict cartilage in the metacarpophalangeal joints of the hands. In addition, we examined the apparatus performance by applying it to healthy volunteers and patients with rheumatoid arthritis (RA). Cartilage deformation, which is thought to be a precursor of destruction of the joints, was successfully depicted by the apparatus, suggesting a potential early diagnosis of RA. [ABSTRACT FROM AUTHOR]