학술논문
Treatment Outcome of Acute Promyelocytic Leukemia with Modified Aida Protocol.
Document Type
Article
Author
Source
Subject
*LEUKEMIA
*MITOXANTRONE hydrochloride
*ANEMIA treatment
*ANTHRACYCLINES
*LEUCOCYTOSIS
*THERAPEUTICS
*PATIENTS
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Language
ISSN
1687-9104
Abstract
We analyzed the outcome of a series of 19 newly diagnosed patients with acute promyelocytic leukemia treated with AIDA modified protocol, using mitoxantrone in place of idarubicin. Eleven patients achieved morphologic CR (58%). The remaining 8 patients had induction failure due to death during induction. Ten of eleven patients in CR achieved molecular remission after induction therapy and all the 8 patients had molecular remission after consolidation. Eight patients completed the three consolidation courses as scheduled and then proceeded to maintenance therapy. After a median follow up of 52 months, no molecular or hematological relapse has occurred. The 4-year disease-free survival is 82%. The study showed the antileukemic efficacy of mitoxantrone and that it could be used as a reasonable option in anthracycline-based strategies in APL. [ABSTRACT FROM AUTHOR]