학술논문
Nationwide registry of glecaprevir plus pibrentasvir in the treatment of HCV in Taiwan.
Document Type
Article
Author
Huang, Chung-Feng; Kuo, Hsing-Tao; Chang, Te-Sheng; Lo, Ching-Chu; Hung, Chao-Hung; Huang, Chien-Wei; Chong, Lee-Won; Cheng, Pin-Nan; Yeh, Ming-Lun; Peng, Cheng-Yuan; Cheng, Chien-Yu; Huang, Jee-Fu; Bair, Ming-Jong; Lin, Chih-Lang; Yang, Chi-Chieh; Wang, Szu-Jen; Hsieh, Tsai-Yuan; Lee, Tzong-Hsi; Lee, Pei-Lun; Wu, Wen-Chih
Source
Subject
*ITCHING
*TREATMENT effectiveness
*
Language
ISSN
2045-2322
Abstract
The study evaluated the real-world treatment outcomes of Glecaprevir/pibrentasvir (GLE/PIB) including effectiveness, safety and healthcare resource utilization based on a nation-wide registry in Taiwan. The Taiwan HCV Registry (TACR) is a nation-wide platform organized and supervised by the Taiwan Association for the Study of the Liver. Data were analyzed for patients treated with GLE/PIB, including 3144 patients who had treatment outcome available. The primary endpoint was sustained virological response (SVR12, undetectable HCV RNA throughout 12 weeks of end-of-treatment). The overall SVR12 rate was 98.9% (3110/3144), with 98.8%, 99.4% and 100% in patients receiving 8 weeks, 12 weeks, and 16 weeks of GLE/PIB respectively. The SVR12 rate in the treatment-naïve cirrhotic patients receiving 8 weeks of GLE/PIB was 98.2% (108/110). The most common AEs were fatigue (7.5%), pruritus (6.7%) and dizziness (1.5%). The mean number of outpatient visits during the GLE/PIB was 5.94 visits for patients treated with 8 weeks, significantly different from the patients treated with 12 weeks of GLE/PIB (6.90 visits). The results support the effectiveness and safety of GLE/PIB treatment in real-world clinical practice, and provide further evidence that the shorter, 8-week GLE/PIB regimen is effective and cost-saving. [ABSTRACT FROM AUTHOR]