학술논문
Decreased survival in necrotizing enterocolitis is significantly associated with neonatal and maternal blood group: the AB isoagglutinin hypothesis.
Document Type
Article
Author
Source
Subject
*ACADEMIC medical centers
*BLOOD groups
*CONFIDENCE intervals
*NEONATAL necrotizing enterocolitis
*NEONATAL intensive care
*SURVIVAL analysis (Biometry)
*NEONATAL intensive care units
*PROPORTIONAL hazards models
*RETROSPECTIVE studies
*KAPLAN-Meier estimator
*BLOOD group incompatibility
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Language
ISSN
0743-8346
Abstract
Objective:To determine the effect of neonatal and maternal blood group on the mortality risk from necrotizing enterocolitis (NEC).Study Design:Retrospective chart review of all neonates admitted to the neonatal intensive care unit over 24 years. Data on birth date, gestational age, maternal/neonatal blood group, number of transfusions, and survival time (defined as date of birth to date of death/discharge) were collected on those with NEC.Result:276 neonates with Bell stage II-III NEC were analyzed. AB neonates had a significantly higher risk of mortality from NEC compared with other blood groups (HR 2.87; 95% CI 1.40 to 5.89; P=0.003). Multivariate analysis showed AB blood group to be an independent risk factor for mortality from NEC.Conclusion:Neonatal and maternal blood groups are significantly associated with a neonate's survival from NEC. The increased mortality of AB neonates may be related to factors such as neonatal blood group antigens and/or transplacental transfer of isoagglutinins. [ABSTRACT FROM AUTHOR]