학술논문
1,6-Nucleophilic Di- and Trifluoromethylation of para -Quinone Methides with Me 3 SiCF 2 H/Me 3 SiCF 3 Facilitated by CsF/18-Crown-6.
Document Type
Article
Author
Source
Subject
Language
ISSN
1420-3049
Abstract
The direct 1,6-nucleophilic difluoromethylation, trifluoromethylation, and difluoroalkylation of para-quinone methides (p-QMs) with Me3SiRf (Rf = CF2H, CF3, CF2CF3, CF2COOEt, and CF2SPh) under mild conditions are described. Although Me3SiCF2H shows lower reactivity than Me3SiCF3, it can react with p-QMs promoted by CsF/18-Crown-6 to give structurally diverse difluoromethyl products in good yields. The products can then be further converted into fluoroalkylated para-quinone methides and α-fluoroalkylated diarylmethanes. [ABSTRACT FROM AUTHOR]