학술논문
Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis.
Document Type
Journal Article
Author
Maryandyshev, Andrey; Pontali, Emanuele; Tiberi, Simon; Akkerman, Onno; Ganatra, Shashank; Sadutshang, Tsetan Dorji; Alffenaar, Jan-Willem; Amale, Rohit; Mullerpattan, Jai; Topgyal, Sonam; Udwadia, Zarir Farokh; Centis, Rosella; D'Ambrosio, Lia; Sotgiu, Giovanni; Battista Migliori, Giovanni; Migliori, Giovanni Battista
Source
Subject
*DRUG therapy for tuberculosis
*DRUG resistance in microorganisms
*ANTITUBERCULAR agents
*TUBERCULOSIS treatment
*TUBERCULOSIS
*TUBERCULOSIS microbiology
*COMBINATION drug therapy
*HETEROCYCLIC compounds
*IMIDAZOLES
*QUINOLINE
*THERAPEUTICS
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Language
ISSN
1080-6040
Abstract
We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options. [ABSTRACT FROM AUTHOR]