학술논문
Identification of a New Class of Inhibitors of the Voltage-Gated Potassium Channel, K[sub v]1.3, with Immunosuppressant Properties.
Document Type
Article
Author
Schmalhofer, William A.; Jianming Bao; McManus, Owen B.; Green, Brian; Matyskiela, Mary; Wunderler, Denise; Bugianesi, Randal M.; Felix, John P.; Hanner, Markus; Linde-Arias, Ana-Rosa; Ponte, Cristiano G.; Velasco, Lucia; Koo, Gloria; Staruch, Mary Jo; Shouwu Miao; Parsons, William H.; Rupprecht, Kathleen; Slaughter, Robert S.
Source
Subject
*POTASSIUM channels
*T cells
*
Language
ISSN
0006-2960
Abstract
Identifies the inhibitors of the voltage-gated potassium channel with immunosuppressant properties. Pathway of T cell activation; Block of the voltage-gated potassium channel in human T-lymphocytes; Correlation between binding of trans disubstituted cyclohexyl isomers and C-type channel inactivation.