학술논문
Germline configuration of nfkb2, c-rel and bcl3 in childhood acute lymphoblastic leukemia (ALL).
Document Type
Journal Article
Author
Source
Subject
*LYMPHOBLASTIC leukemia
*CELL lines
*TRANSCRIPTION factors
*COMPARATIVE studies
*DNA
*RESEARCH methodology
*MEDICAL cooperation
*PROTEIN-tyrosine kinases
*PROTEINS
*RESEARCH
*DNA-binding proteins
*EVALUATION research
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Language
ISSN
0887-6924
Abstract
The well-known family of NF-kappaB/Rel transcription factors is a central regulator of growth, differentiation and apoptosis in hematopoietic cell lineages. There is increasing evidence for their role in malignant transformation, especially in lymphomas. To study the possible involvement of NF-kappaB/Rel genes in the development of pediatric acute lymphoblastic leukemia (ALL), DNA samples from 140 patients were examined by Southern blot analysis. All samples revealed germline configuration of nfkb2, c-rel, and bcl3, indicating that structural alterations of these members of the NF-kappaB/Rel family are extremely rare, if existing at all in childhood ALL. [ABSTRACT FROM AUTHOR]