학술논문
Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking.
Document Type
Article
Author
Source
Subject
*ANTIHYPERTENSIVE agents
*VALSARTAN
*DENDRITIC cells
*SPINE
*AMPA receptors
*HIPPOCAMPUS (Brain)
*NEURONS
*GENE expression
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Language
ISSN
0006-291X
Abstract
Highlights: [•] Valsartan increases dendritic spine density in primary hippocampal neurons. [•] Valsartan increases the puncta number of postsynaptic scaffold PSD-95. [•] Valsartan selectively regulates expression of NMDA and AMPA receptor subunits. [•] Valsartan upregulates synaptic signaling molecules CaMKIIα and phospho-CDK5. [ABSTRACT FROM AUTHOR]