학술논문
Recombinant Human Relaxin in the Treatment of Systemic Sclerosis With Diffuse Cutaneous Involvement.
Document Type
Article
Author
Khanna, Dinesh; Clements, Philip J.; Furst, Daniel E.; Korn, Joseph H.; Ellman, Michael; Rothfield, Naomi; Wigley, Fredrick M.; Moreland, Larry W.; Silver, Richard; Kim, Youn H.; Steen, Virginia D.; Firestein, Gary S.; Kavanaugh, Arthur F.; Weisman, Michael; Mayes, Maureen D.; Collier, David; Csuka, Mary E.; Simms, Robert; Merkel, Peter A.; Medsger Jr., Thomas A.
Source
Subject
*RELAXIN
*SYSTEMIC scleroderma
*PLACEBOS
*RANDOMIZED controlled trials
*BLIND experiment
*THERAPEUTICS
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Language
ISSN
0004-3591
Abstract
The article discusses the potentials of recombinant human relaxin in treating systemic sclerosis (SSc) with diffuse cutaneous involvement. It utilizes large randomized, double-blind, placebo controlled trial. Renovascular systems of patients with SSc are sensitive to changes in blood flow and other stimuli. It shows that recombinant human relaxin with subcutaneous (SC) infusion over 24 weeks is not better than placebo in improving the skin score and pulmonary conditions in patients.