학술논문
Mimicking SIV chimpanzee viral evolution toward HIV‐1 during cross‐species transmission.
Document Type
Article
Author
Source
Subject
*CHIMPANZEES
*VIRAL genomes
*VIRAL load
*VIRAL transmission
*MICE
*
*
*
*
Language
ISSN
0047-2565
Abstract
HIV‐1 evolved from SIV during cross‐species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV‐1 Group M using humanized mice. High viral loads, rapid CD4+ T‐cell decline, and non‐synonymous substitutions were identified throughout the viral genome suggesting viral adaptation. [ABSTRACT FROM AUTHOR]