학술논문
Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer.
Document Type
Article
Author
Lafont, Charlotte; Paillaud, Elena; Bertolus, Chloe; Baron, Melany; Caillet, Philippe; Bouvard, Eric; Laurent, Marie; Salvan, Didier; Chaumette, Laurence; Decker, Laure de; Piot, Benoit; Barry, Beatrix; Raynaud-Simon, Agathe; Sauvaget, Elisabeth; Minard, Aurélien; Anota, Amélie; Panjo, Henri; Brugel, Lydia; Canouï-Poitrine, Florence
Source
Subject
*HEAD & neck cancer
*OLDER patients
*GERIATRIC assessment
*QUALITY of life
*FUNCTIONAL status
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Language
ISSN
0027-8874
Abstract
Due to the location and toxicity of treatments, head and neck cancer (HNC) has a major impact on quality of life (QoL). Objective: to assess the effects of geriatric-assessment (GA)-driven interventions on QoL over 2 years in older adults with HNC. EGeSOR was a randomized study of HNC patients aged ≥65, receiving a pretreatment GA, a geriatric intervention and follow-up (intervention) or standard of care (control). The primary endpoint was QoL score using the European Organisation for Research and Treatment of Cancer's (EORTC QLQ-C30) and HNC (QLQ-HN35) QoL questionnaires over 24 months. In total, 475 patients were included (median age: 75.3; women: 31%; oral cancer: 44%). QoL scores improved over 24 months with various trajectories, without significant differences between the groups. A total of 74% of patients (interventional group) did not receive the complete intervention. Cancer characteristics, functional status, and risk of frailty were associated with change in the Global Health Status QoL score. There is a need to develop an alternative model of implementation such as patient-centered health-care pathways. Trial registration NCT02025062. [ABSTRACT FROM AUTHOR]