학술논문
Characterization of the B*5002-Cw*0602- DRB1*0406-DQB1*0402 Haplotype: impact on the unrelated-bone marrow donor search strategy.
Document Type
Article
Author
Source
Subject
*HLA histocompatibility antigens
BONE marrow examination
Language
ISSN
0001-2815
Abstract
Abstract: Improvements in HLA-typing by DNA-based methods now allow accurate genotyping of unrelated bone marrow (UBM) donors and recipients and also definition of haplotypes. In this regard, B*5002 has been predicted in linkage disequilibrium with Cw*0602, DRB1*0406 and DQB1*0402 based on the frequency of allele coexistence. Here, we confirm this assumption by HLA genotyping of four informative families and three unrelated individ-uals. In the four families, the extended haplotype HLA-B*5002, -Cw*0602, -DRB1* 0406, DQB1*0402 can be definitely assigned by the mode of heritance. Furthermore, this association of alleles was also found in the three B*5002 unrelated individuals. Knowledge of the frequent linkage disequilibrium of these rare alleles can improve UBM donor search strategies. [ABSTRACT FROM AUTHOR]