학술논문
Synthesis and DNA studies of a copper(II) complex of 5,6-dihydro-5,6-epoxy-1,10-phenanthroline.
Document Type
Article
Source
Subject
*COMPLEX compounds synthesis
*DNA & metals
*COPPER compounds
*PHENANTHROLINE derivatives
*INFRARED spectroscopy
*ULTRAVIOLET-visible spectroscopy
*X-ray diffraction
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Language
ISSN
0095-8972
Abstract
A new copper(II) complex, [Cu(epoxy)(phen)(NO3)](NO3)·H2O (epoxy = 5,6-dihydro-5,6-epoxy-1,10-phenanthroline, phen = 1,10-phenanthroline), has been synthesized and characterized by elemental analysis, IR and UV–vis spectroscopy, and single crystal X-ray diffraction. The complex crystallized in a monoclinic system with space groupP21/n,a = 13.3199(8) Å,b = 11.2917(7) Å,c = 16.0832(9) Å,α = 90°,β = 107.827(4)°, andγ = 90°. The complex cation possesses a distorted octahedral geometry, with Jahn–Teller distortion occurring in the CuN4O2core. The binding interaction with calf thymus DNA (CT–DNA) was investigated by UV–vis and fluorescence spectroscopy, cyclic voltammetry, and viscometry. The results support a partially intercalative binding mode. Efficient cleavage of plasmid DNA by the complex was observed by gel electrophoresis. [ABSTRACT FROM AUTHOR]