학술논문
Unilateral Phrenic Nerve Palsy in Infants with Congenital Zika Syndrome.
Document Type
Journal Article
Author
Source
Subject
*ZIKA virus infections
*CONGENITAL disorders
*PHRENIC nerve
*RADIOGRAPHS
*DISEASES
*DIAPHRAGM innervation
*COMMUNICABLE diseases
*PERIPHERAL neuropathy
*PREGNANCY complications
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Language
ISSN
1080-6040
Abstract
Since the first identification of neonatal microcephaly cases associated with congenital Zika virus infection in Brazil in 2015, a distinctive constellation of clinical features of congenital Zika syndrome has been described. Fetal brain disruption sequence is hypothesized to underlie the devastating effects of the virus on the central nervous system. However, little is known about the effects of congenital Zika virus infection on the peripheral nervous system. We describe a series of 4 cases of right unilateral diaphragmatic paralysis in infants with congenital Zika syndrome suggesting peripheral nervous system involvement and Zika virus as a unique congenital infectious cause of this finding. All the patients described also had arthrogryposis (including talipes equinovarus) and died from complications related to progressive respiratory failure. [ABSTRACT FROM AUTHOR]