학술논문
Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19).
Document Type
Article
Author
Boucau, Julie; Uddin, Rockib; Marino, Caitlin; Regan, James; Flynn, James P; Choudhary, Manish C; Chen, Geoffrey; Stuckwisch, Ashley M; Mathews, Josh; Liew, May Y; Singh, Arshdeep; Reynolds, Zahra; Iyer, Surabhi L; Chamberlin, Grace C; Vyas, Tammy D; Vyas, Jatin M; Turbett, Sarah E; Li, Jonathan Z; Lemieux, Jacob E; Barczak, Amy K
Source
Subject
*REVERSE transcriptase polymerase chain reaction
*COVID-19
*COMBINATION drug therapy
*SEQUENCE analysis
*ANTIVIRAL agents
*RITONAVIR
*DESCRIPTIVE statistics
*GENOMES
*VIROLOGY
*DATA analysis software
*LONGITUDINAL method
*
*
*
*
*
*
*
*
*
*
Language
ISSN
1058-4838
Abstract
We enrolled 7 individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10 copies/mL) were detected after rebound for a median of 17 days after initial diagnosis. Three had culturable virus for up to 16 days after initial diagnosis. No known resistance-associated mutations were identified. [ABSTRACT FROM AUTHOR]