학술논문
Polymorphism in 2-Chlorobenzamide: Run of the Mill or Not?
Document Type
Article
Author
Source
Subject
*POLYMORPHISM (Crystallography)
*BENZAMIDE
*LOW temperature engineering
*CRYSTAL structure
*MILLING (Metalwork)
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Language
ISSN
1528-7483
Abstract
Structures of two very similar polymorphic forms of 2-chlorobenzamide have been obtained at low temperature. The metastable α-form is very susceptible to grinding, a property not initially realized considering the polymorphs have been reported in the literature for many years. Systematic milling studies have been carried out in a search for other polymorphic forms and to assess the rate of any polymorphic change(s). No new polymorphs were found, though a computational search for low energy structures suggested a complex crystal-energy landscape. An experimental polymorph screen was also carried out. [ABSTRACT FROM AUTHOR]