학술논문
A Rapid and Sensitive Liquid Chromatography - Tandem Mass Spectrometry Method for Determination of Olopatadine Concentration in Human Plasma.
Document Type
Article
Author
Source
Subject
*LIQUID chromatography
*TANDEM mass spectrometry
*BLOOD plasma
*PHARMACOKINETICS
*PROTEIN analysis
*DICHLOROMETHANE
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Language
ISSN
0146-4760
Abstract
The article discusses a sensitive and rapid method based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) method for measuring olopatadine concentration in human plasma. The study used protein precipitation to carry out sample preparations, followed by liquid-liquid extraction (LLE) with ethyl acetate/dichloromethane. It states that the method has sensitivity with a lower limit of quantification (LLOQ) of 0.2 ng/mL and was used for the pharmacokinetic studies of olopatadine.