학술논문
Sitagliptin, a Selective DPP-4 Inhibitor, and Metformin Have Complementary Effects to Increase Active GLP-1 Concentrations.
Document Type
Article
Author
Source
Subject
*HYPOGLYCEMIC agents
*CHEMICAL inhibitors
*GLUCAGON-like peptide 1
*PLACEBOS
*CLINICAL trials
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Language
ISSN
0012-1797
Abstract
The article highlights a study which examines the potential complementary effects of sitagliptin (SITA) and metformin (MF) to increase active GLP-1 concentrations. A randomized placebo-controlled study was conducted in 16 healthy adults. In each 2-day treatment period, subjects received either SITA 100 mg q.d., MF 500 mg b.i.d., co-administration of SITA 100 mg q.d. and MF 500 mg b.i.d. Results show that SITA alone and MF alone each increased post-meal incremental active GLP-1 concentrations.