부산대학교 도서관

Perhaps experience of seasonal influenza evolution coupled with the proofreading capacity of the SARS-CoV-2 polymerase led scientists to believe that SARS-CoV-2 would evolve relatively slowly. For SARS-CoV-2, it was quickly identified that a multi-basic furin cleavage site in spike was an essential difference between SARS-CoV-2 and both SARS-CoV and other closely related bat coronaviruses (Coutard et al. 2020; Hoffmann et al. 2020). However, with hindsight, it seems evolving during a pandemic allowed SARS-CoV-2 to overcome these restrictive bottlenecks seen in seasonal viruses and evolve differently from influenza. Early in the firstwave of the COVID-19 pandemic, one might be forgiven for suggesting that SARS-CoV-2 mutations were not a major cause for concern; there were other more pressing issues such as designing and testing new vaccines (Grubaugh et al. 2020). [Extracted from the article]