학술논문
TOMM40 Alterations in Alzheimer's Disease Over a 2-Year Follow-Up Period.
Document Type
Article
Author
Source
Subject
*ALZHEIMER'S disease diagnosis
*ALZHEIMER'S disease treatment
*DIAGNOSIS of neurological disorders
*THERAPEUTICS
*NEUROLOGICAL disorders
*TREATMENT of dementia
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Language
ISSN
1387-2877
Abstract
We previously reported TOMM40 to be significantly down-regulated in whole blood of Alzheimer's disease (AD) subjects at baseline and after one-year. In this longitudinal follow-up study of TOMM40 expression up to 2 years, we performed 6-monthly assessments for the first year and 2nd year blood sampling on 27 probable AD subjects compared with age- and gender-matched controls. TOMM40 gene expression remained significantly lower in AD patients at all time-points compared to controls, supported by confirmatory RT-PCR results. Our findings of consistently lower TOMM40 expression on longitudinal 2-year sampling support its potential role as a diagnostic blood AD biomarker. [ABSTRACT FROM AUTHOR]