학술논문
A multicenter cohort study of pregnancy outcomes among women with laboratory-confirmed H1N1 influenza.
Document Type
Article
Author
Source
Subject
*BIRTH weight
*CHI-squared test
*CONFIDENCE intervals
*EPIDEMIOLOGY
*FISHER exact test
*GOODNESS-of-fit tests
*PREMATURE infants
*LONGITUDINAL method
*EVALUATION of medical care
*MEDICAL cooperation
*MULTIVARIATE analysis
*PREGNANCY
*RESEARCH
*RESEARCH funding
*T-test (Statistics)
*LOGISTIC regression analysis
*DATA analysis
*DISEASE incidence
*CASE-control method
*INFLUENZA A virus, H1N1 subtype
*DATA analysis software
*STATISTICAL models
*DESCRIPTIVE statistics
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Language
ISSN
0743-8346
Abstract
Objective:To evaluate associations between laboratory-confirmed 2009 H1N1 influenza infection and obstetric and neonatal outcomes.Study design:A multicenter cohort study was performed comparing laboratory-confirmed cases of 2009 H1N1 infection during pregnancy (N=142) with matched controls (N=710). Subanalysis was also performed comparing severely infected (hospitalized) women with controls.Result:No outcome differences were noted in comparing all women with H1N1 with controls. Women with severe infection had a higher incidence of delivering a small for gestational age (SGA) infant: 18.8% (6/32) versus 7.4% (52/707), adjusted odds ratio 2.35 (95% confidence interval 1.03, 5.36, P=0.02). Mean birth weight was 3013.0 g among severely infected women and 3223.3 g in controls (P=0.08), and incidence of preterm delivery was 25.0% (8/32) and 11.6% (82/710) (P=0.08), respectively.Conclusion:Pregnant women with mild clinical illness secondary to 2009 H1N1 were not at a greater risk of adverse pregnancy outcomes. However, severely infected women were more likely to deliver SGA infants. [ABSTRACT FROM AUTHOR]