학술논문
Fast, Solvent-Free, Microwave-Promoted Friedlander Annulation with a Reusable Solid Catalyst.
Document Type
Article
Author
Source
Subject
*QUINOLINE
*CATALYSTS
*SULFONIC acids
*MICROWAVES
*IRRADIATION
*
*
*
*
Language
ISSN
0039-7911
Abstract
A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedlander cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30 min), the reaction was also feasible under conventional heating (with fair to good yields in about 5 h). [ABSTRACT FROM AUTHOR]