학술논문
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition.
Document Type
Article
Author
Source
Subject
*LYSOSOMES
*ANDROGEN receptors
*PROSTATE cancer
*MOLECULAR biology
*LIFE sciences
*METABOLISM
*CYTOLOGY
*
*
*
*
*
*
Language
ISSN
2375-2548
Abstract
The article explores the phosphatidylinositol-5-phosphate 4-kinases (PI5P4K), a family of lipid kinases that regulate pools of intracellular Phosphatidylinositol (PI) and demonstrate that the PI5P4Kα isoform influences androgen receptor (AR) signaling, which supports prostate cancer (PCa) cell survival. It concludes that multiple PCa cell models demonstrate marked survival vulnerability following stable PI5P4Kα inhibition.