부산대학교 도서관

Background: National screening programmes increase the proportion of T1 colorectal cancers. Local excision may be possible, butthe risk of lymph node metastases (LNMs) could jeopardize long-term outcomes. The aim of the presentstudy was to review the association between histopathological findings and LNMs in T1 colorectal cancer. Methods: A systematic literature search was conducted using PubMed, Embase, and Cochrane online databases. Studies investigating the association between one or more histopathological factors and LNMs in patients who underwent resection for T1 colorectal cancerwere included. Results: Sixteen observational studies were included in the meta-analysis, including a total of 10 181 patients, of whom 1 307 had LNMs. Lymphovascular invasion (odds ratio (OR) 7.42; P < 0 .001), tumour budding (OR 4.00; P < 0 .001), depth of submucosal invasion, whether measured as at least 1000 mm (OR 3.53; P < 0.001) or Sm2-3 (OR 2.12; P = 0.020), high tumour grade (OR 3.75; P < 0.001), polypoid growth pattern (OR 1.59; P = 0.040), and rectal location of tumour (OR 1.36; P = 0.003) were associated with LNMs. Conclusion: Distincthistopathological factors associated with nodal metastases in T1 colorectal cancercan aid selection ofpatients forlocal excision ormajorexcisional surgery. [ABSTRACT FROM AUTHOR]