학술논문
Messages from forgotten friends: classic cell adhesion molecules inhibit regeneration too.
Document Type
Article
Author
Source
Subject
*CELL adhesion
*REGENERATION (Biology)
*SPINAL cord injuries
*THERAPEUTICS
*AXONS
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Language
ISSN
0261-4189
Abstract
A necessary step toward complete functional recovery after spinal cord injury is the regeneration of axons. Axon regrowth after injury is prevented by a myriad of intrinsic and extrinsic factors. In this issue of The EMBO Journal, Huang et al () demonstrate that the cell adhesion molecule NB-3 ( CNTN6) functions as a major brake on axon regrowth when it is activated by NB-3 from scar-forming cells at the injury site. Disruption of this NB-3 trans-cellular signaling led to impressive axon regrowth after spinal cord transection. [ABSTRACT FROM AUTHOR]