학술논문
MOZ-TIF2-mediated destruction of CBP/p300 is blocked by calpain inhibitor 2.
Document Type
Letter
Author
Source
Subject
*ACUTE myeloid leukemia
*CHROMOSOMAL proteins
*CALPAIN
*GENES
*PROTEIN kinases
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Language
ISSN
0887-6924
Abstract
The article presents a study to examine the role of CPM and p300 in cell MOZ-TIF2. It states that the oncogenic fusion protein MOZ-TIF2 results from reciprocal chromosomal rearrangements in the MOZ-MYST3-KAT6A gene in acute myeloid leukemia. It observers that the cell permeant calpain and cathepsin inhibitor CPI-2 blocks the effect of MOZ-TIF2 and restore CBP expression to normal levels and rescuing MOZ-TIF2 mediated gene repression.