부산대학교 도서관

Background: Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. We investigated the association of gestational age (GA) at birth with body size from infancy through adolescence. Methods and findings: We conducted a two-stage individual participant data (IPD) meta-analysis using data from 253,810 mother–child dyads from 16 general population-based cohort studies in Europe (Denmark, Finland, France, Italy, Norway, Portugal, Spain, the Netherlands, United Kingdom), North America (Canada), and Australasia (Australia) to estimate the association of GA with body mass index (BMI) and overweight (including obesity) adjusted for the following maternal characteristics as potential confounders: education, height, prepregnancy BMI, ethnic background, parity, smoking during pregnancy, age at child's birth, gestational diabetes and hypertension, and preeclampsia. Pregnancy and birth cohort studies from the LifeCycle and the EUCAN-Connect projects were invited and were eligible for inclusion if they had information on GA and minimum one measurement of BMI between infancy and adolescence. Using a federated analytical tool (DataSHIELD), we fitted linear and logistic regression models in each cohort separately with a complete-case approach and combined the regression estimates and standard errors through random-effects study-level meta-analysis providing an overall effect estimate at early infancy (>0.0 to 0.5 years), late infancy (>0.5 to 2.0 years), early childhood (>2.0 to 5.0 years), mid-childhood (>5.0 to 9.0 years), late childhood (>9.0 to 14.0 years), and adolescence (>14.0 to 19.0 years). GA was positively associated with BMI in the first decade of life, with the greatest increase in mean BMI z-score during early infancy (0.02, 95% confidence interval (CI): 0.00; 0.05, p < 0.05) per week of increase in GA, while in adolescence, preterm individuals reached similar levels of BMI (0.00, 95% CI: −0.01; 0.01, p 0.9) as term counterparts. The association between GA and overweight revealed a similar pattern of association with an increase in odds ratio (OR) of overweight from late infancy through mid-childhood (OR 1.01 to 1.02) per week increase in GA. By adolescence, however, GA was slightly negatively associated with the risk of overweight (OR 0.98 [95% CI: 0.97; 1.00], p 0.1) per week of increase in GA. Although based on only four cohorts (n = 32,089) that reached the age of adolescence, data suggest that individuals born very preterm may be at increased odds of overweight (OR 1.46 [95% CI: 1.03; 2.08], p < 0.05) compared with term counterparts. Findings were consistent across cohorts and sensitivity analyses despite considerable heterogeneity in cohort characteristics. However, residual confounding may be a limitation in this study, while findings may be less generalisable to settings in low- and middle-income countries. Conclusions: This study based on data from infancy through adolescence from 16 cohort studies found that GA may be important for body size in infancy, but the strength of association attenuates consistently with age. By adolescence, preterm individuals have on average a similar mean BMI to peers born at term. In an individual participant data meta-analysis of >250,000 singleton births from 16 birth cohort studies, Dr. Johan Lerbech Vinther and colleagues, explore gestational age at birth and body size from infancy through to adolescence. Author summary: Why was this study done?: ■ Conditions and exposures in early life is suggested to play an important role in development of cardiometabolic health outcomes, including body size. ■ The majority of previous research focused on the impact of size at birth (i.e., birth weight), rather than the timing of birth (i.e., gestational duration). ■ Moreover, we know less about how different contextual factors influence associations between early life risk factors and later body size. What did the researchers do and find?: ■ Our aim was to examine the association of gestational age with body mass index (BMI) and overweight from infancy through adolescence. ■ We used data from 16 cohort studies in Europe, North America, and Australasia, including information on 253,810 mother–child dyads. ■ We found that infants born preterm (<37 completed weeks of gestation) have a lower BMI and lower risk of overweight in infancy than their term counterparts and that this difference attenuates with age. ■ In adolescence, BMI was similar between preterm and term peers, while there was an indication of an increased risk of overweight in very preterm individuals. What do these findings mean?: ■ Our study suggests that, although being born early, preterm infants on average reach the body size as their term peers before adulthood. ■ In line with earlier findings, children born very preterm may even be at increased risk of overweight in adulthood, here already indicated at entrance to adulthood. ■ This last finding must be interpreted with caution, as only four cohorts (n = 32,089) contributed with data in adolescence. ■ In addition, our study is based on data from high-income countries; hence, the findings are not generalisable to low- and middle-income country settings. [ABSTRACT FROM AUTHOR]