학술논문
Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions.
Document Type
Article
Author
Source
Subject
*MULTIPLE myeloma
*BONE marrow transplantation
*DRUG therapy
*GRAFT versus host disease
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Language
ISSN
0268-3369
Abstract
Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted >22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions. [ABSTRACT FROM AUTHOR]