학술논문
E-Cadherin Binding Modulates EGF Receptor Activation.
Document Type
Article
Author
Source
Subject
*CELL motility
*EPITHELIAL cells
*AMINO acids
*GROWTH factors
*KERATINOCYTES
*
*
*
*
Language
ISSN
1541-9061
Abstract
We found that E-cadherin and epidermal growth factor receptor (EGFR) are associated in mammary epithelial cells and that E-cadherin engagement in these cells induces transient activation of EGFR, as previously seen in keratinocytes (37). In contrast, EGFR does not associate with and is not activated by N-cadherin. Analysis of cells expressing chimeric cadherins revealed that the extracellular domain of E-cadherin is required for interaction with and activation of EGFR. This activation results in tyrosine phosphorylation of known EGFR substrates and reduction in focal adhesions. These interactions, however, are not necessary for suppression of cell motility by E-cadherin. [ABSTRACT FROM AUTHOR]