학술논문
Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma.
Document Type
Article
Author
Cidre-Aranaz, Florencia; Li, Jing; Hölting, Tilman L. B.; Orth, Martin F.; Imle, Roland; Kutschmann, Stefanie; Ammirati, Giulia; Ceranski, Katharina; Carreño-Gonzalez, Martha Julia; Kasan, Merve; Marchetto, Aruna; Funk, Cornelius M.; Bestvater, Felix; Bersini, Simone; Arrigoni, Chiara; Moretti, Matteo; Thiel, Uwe; Baumhoer, Daniel; Sahm, Felix; Pfister, Stefan M.
Source
Subject
*EWING'S sarcoma
*GENE ontology
*GENE regulatory networks
*FUNCTIONAL analysis
*CARCINOGENS
*METASTASIS
*CANCER cell growth
*SEVERE combined immunodeficiency
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Language
ISSN
1476-4598
Abstract
Thus, we generated two EwS cell lines (SK-N-MC and TC-71, with lowest I TCF7L1 i expression across the 5 EwS cell lines tested (Supplementary Fig. Ewing sarcoma (EwS), the second most common bone cancer in children and adolescents [[2]], is a highly aggressive malignancy associated with dismal outcome in metastatic disease [[3]], wherefore deciphering mechanisms of metastasis is imperative. Weighted Gene Correlation Network Analysis (WGCNA) based on enriched gene-sets in I TCF7L1- i correlated genes in 166 EwS tumors showed that EwS tumors with low I TCF7L1 i expression were enriched in embryonic pathways (Fig. [Extracted from the article]