부산대학교 도서관

There is increasing evidence that the brain resides in a state of criticality. The purpose of the present work is to characterize the dynamics of individual hippocampal CA1 pyramidal cells and to investigate how it is influenced by changes in Kv7.2/7.3 (M-channel) ion channel modulation, which is known to be key in determining the neuronal excitability. We show that the resting activity of CA1 neurons exhibit random dynamics with low information content, while changes in M-channel modulation move the neuronal activity near a phase transition to richer non-trivial dynamics. We interpret these results as the basis upon which the state of self-organized criticality is built. • Neuronal dynamical state is given by the statistics of the distributions of inter-spike intervals. • In the basal state, cell spiking follows a Poisson-like non-correlated random statistics. • Activation of the PLC signaling cascade with Oxo-M introduces temporal correlations. • These correlations can be interpreted as a shift of the neuronal dynamics towards a critical state. [ABSTRACT FROM AUTHOR]