학술논문
Topological capture of mRNA for silencing gene expression.
Document Type
Article
Author
Source
Subject
*GENE expression
*MESSENGER RNA
*FUNCTIONAL groups
*GENE silencing
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Language
ISSN
1359-7345
Abstract
We describe herein topological mRNA capture using branched oligodeoxynucleotides (ODNs) with multiple reactive functional groups. These fragmented ODNs efficiently formed topological complexes on template mRNA in vitro. In cell-based experiments targeting AcGFP mRNA, the bifurcated reactive ODNs showed a much larger gene silencing effect than the corresponding natural antisense ODN. [ABSTRACT FROM AUTHOR]